S5  Tanycytes - walk between worlds

Vincent Prévot (Lille, France) and Markus Schwaninger (Lübeck)

Live Discussion: Monday, March 22, 2021, 18:00 - 19:00h

Tanycytes are glial cells that line the third ventricle in the mediobasal hypothalamus and extend long processes to blood vessels in the parenchyma. Being in contact with cerebrospinal fluid and blood, tanycytes are ideally positioned to transmit information between periphery and CNS. In support of this concept, previous work has shown that tanycytes are able to control the neuroendocrine output of the hypothalamus and to transport key metabolic signals from the periphery into the hypothalamus. However, recent evidence has emphasized that tanycytes are heterogeneous with respect to gene expression and their connectivity with hypothalamic nuclei suggesting that the functional repertoire of these peculiar cells might be even larger. This symposium will explore the physiology of tanycytes as master regulators of the hypothalamus, with special attention to their emerging role in the control of body weight.

We gratefully acknowledge the financial support of Chroma.
S5-1 Manon Duquenne, Lille, France
Implication of leptin receptors expressed in hypothalamic tanycytes in the central control of energy homeostasis

S5-2 Irina Vladimirova Milanova, Amsterdam, Netherlands
Microglial insulin signalling plays a role in the progression of dietary-induced obesity

S5-3 Ruben Nogueiras, Santiago de Compostela, Spain
Hypothalamic dopamine system and its interaction with peripheral tissues to control energy balance

S5-4 Jens Brüning, Cologne, Germany
Hypothalamic control of median emminence barrier function

S5-5 Fanny Valérie Langlet, Lausanne, Switzerland
To infer tanycyte-neuron communications through single-cell transcriptomics data

S5-6 Natascha Klaus, Lübeck, Germany
Characterisation of intracellular signal transduction of adrenoceptors and GABAB-receptors in tanycytes