S14  Post-translational modifications of proteome in neuronal development

Mateusz Ambrozkiewicz (Berlin) and Victor Tarabykin (Berlin)

Live Discussion: Thursday, March 25, 2021, 17:00 - 18:00h

Post-translational modifications of nascent polypeptide chains confer structural and functional alterations to their functions. Given a multitude of possible modifications of immature proteins by post-translational machineries, existence of such system allows for molecular adaptation of the proteome to cellular and physiological states. This is of particular importance to developing neurons, regarding a plethora of morphological transitions and physiological maturation during development. In this symposium, we will try to shed light on the molecular and cellular functions of some types of post-translational modifications in neurons and present the newest advances in determining the physiological roles of these modifications, such as ubiquitylation, acetylation, neddylation, or phosphorylation.

S14-1 Annette Monika Vogl, South San Francisco, USA
Studying Ubiquitin & Ubiquitin-like proteins - Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates the actin cytoskeleton in developing neurons

S14-2 Stephanie L Gupton, Chapel Hill, USA
TRIM9 and TRIM67: Yin Yang E3 ubiquitin ligases in neuronal morphogenesis

S14-3 Santiago Camblor-Perujo, Cologne, Germany
Regulation of Neuronal Cell Fate Determination by Endocytic Adaptor AP-2

S14-4 Mateusz Ambrozkiewicz, Berlin, Germany
The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc

S14-5 Matthew Lee Kraushar, Berlin, Germany
Protein synthesis in neocortex development at near-atomic resolution

S14-6 Bahar Aksan, Heidelberg, Germany
Molecular mechanisms of structural maintenance and plasticity in neurons