S14 Post-translational modifications of proteome in neuronal development
Mateusz Ambrozkiewicz (Berlin) and Victor Tarabykin (Berlin)
Live Discussion: Thursday, March 25, 2021, 17:00 - 18:00h
Post-translational modifications of nascent polypeptide chains confer structural and functional alterations to their functions. Given a multitude of possible modifications of immature proteins by post-translational machineries, existence of such system allows for molecular adaptation of the proteome to cellular and physiological states. This is of particular importance to developing neurons, regarding a plethora of morphological transitions and physiological maturation during development. In this symposium, we will try to shed light on the molecular and cellular functions of some types of post-translational modifications in neurons and present the newest advances in determining the physiological roles of these modifications, such as ubiquitylation, acetylation, neddylation, or phosphorylation.